RapamycinFungusV1, Main, Exploration, bibRecord, 000481

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Identifieur interne : 000481 ( Main/Exploration ); précédent : 000480; suivant : 000482

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Auteurs : Adiel Cohen ; Aline Habib [Israël] ; Dana Laor [Israël] ; Sudhanshu Yadav ; Martin Kupiec [Israël] ; Ronit Weisman [Israël]

Source :

The Journal of biological chemistry [ 1083-351X ] ; 2018.

RBID : pubmed:29632066

Descripteurs français

English descriptors

KwdEn :
- Chromatin (genetics), Chromatin (metabolism), Gene Silencing (MeSH), Heterochromatin (genetics), Heterochromatin (metabolism), Histones (genetics), Histones (metabolism), Mechanistic Target of Rapamycin Complex 2 (genetics), Mechanistic Target of Rapamycin Complex 2 (metabolism), Multiprotein Complexes (genetics), Multiprotein Complexes (metabolism), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Schizosaccharomyces (genetics), Schizosaccharomyces (growth & development), Schizosaccharomyces (metabolism), Schizosaccharomyces pombe Proteins (genetics), Schizosaccharomyces pombe Proteins (metabolism), Telomere (genetics), Telomere (metabolism).
MESH :
- chemical , genetics : Chromatin, Heterochromatin, Histones, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Protein-Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins.
- chemical , metabolism : Chromatin, Heterochromatin, Histones, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Protein-Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins.
- genetics : Schizosaccharomyces, Telomere.
- growth & development : Schizosaccharomyces.
- metabolism : Schizosaccharomyces, Telomere.
- Gene Silencing, Phosphorylation.

Abstract

The conserved serine/threonine protein kinase target of rapamycin (TOR) is a major regulator of eukaryotic cellular and organismal growth and a valuable target for drug therapy. TOR forms the core of two evolutionary conserved complexes, TOR complex 1 (TORC1) and TORC2. In the fission yeast Schizosaccharomyces pombe, TORC2 responds to glucose levels and, by activating the protein kinase Gad8 (an orthologue of human AKT), is required for well-regulated cell cycle progression, starvation responses, and cell survival. Here, we report that TORC2-Gad8 is also required for gene silencing and the formation of heterochromatin at the S. pombe mating-type locus and at subtelomeric regions. Deletion of TORC2-Gad8 resulted in loss of the heterochromatic modification of histone 3 lysine 9 dimethylation (H3K9me2) and an increase in euchromatic modifications, including histone 3 lysine 4 trimethylation (H3K4me3) and histone 4 lysine 16 acetylation (H4K16Ac). Accumulation of RNA polymerase II (Pol II) at subtelomeric genes in TORC2-Gad8 mutant cells indicated a defect in silencing at the transcriptional level. Moreover, a concurrent decrease in histone 4 lysine 20 dimethylation (H4K20me2) suggested elevated histone turnover. Loss of gene silencing in cells lacking TORC2-Gad8 is partially suppressed by loss of the anti-silencer Epe1 and fully suppressed by loss of the Pol II-associated Paf1 complex, two chromatin regulators that have been implicated in heterochromatin stability and spreading. Taken together, our findings suggest that TORC2-Gad8 signaling contributes to epigenetic stability at subtelomeric regions and the mating-type locus in S. pombe.

DOI: 10.1074/jbc.RA118.002270
PubMed: 29632066
PubMed Central: PMC5971458

Affiliations:

Israël

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000580
to stream Main, to step Curation: 000580

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.</title>
<author><name sortKey="Cohen, Adiel" sort="Cohen, Adiel" uniqKey="Cohen A" first="Adiel" last="Cohen">Adiel Cohen</name>
<affiliation><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</nlm:affiliation>
<wicri:noCountry code="subField">Israel and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Habib, Aline" sort="Habib, Aline" uniqKey="Habib A" first="Aline" last="Habib">Aline Habib</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laor, Dana" sort="Laor, Dana" uniqKey="Laor D" first="Dana" last="Laor">Dana Laor</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yadav, Sudhanshu" sort="Yadav, Sudhanshu" uniqKey="Yadav S" first="Sudhanshu" last="Yadav">Sudhanshu Yadav</name>
<affiliation><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</nlm:affiliation>
<wicri:noCountry code="subField">Israel and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kupiec, Martin" sort="Kupiec, Martin" uniqKey="Kupiec M" first="Martin" last="Kupiec">Martin Kupiec</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisman, Ronit" sort="Weisman, Ronit" uniqKey="Weisman R" first="Ronit" last="Weisman">Ronit Weisman</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and ronitwe@openu.ac.il.</nlm:affiliation>
<country wicri:rule="url">Israël</country>
<wicri:regionArea>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana</wicri:regionArea>
<wicri:noRegion>4353701 Ranana</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29632066</idno>
<idno type="pmid">29632066</idno>
<idno type="doi">10.1074/jbc.RA118.002270</idno>
<idno type="pmc">PMC5971458</idno>
<idno type="wicri:Area/Main/Corpus">000580</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000580</idno>
<idno type="wicri:Area/Main/Curation">000580</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000580</idno>
<idno type="wicri:Area/Main/Exploration">000580</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.</title>
<author><name sortKey="Cohen, Adiel" sort="Cohen, Adiel" uniqKey="Cohen A" first="Adiel" last="Cohen">Adiel Cohen</name>
<affiliation><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</nlm:affiliation>
<wicri:noCountry code="subField">Israel and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Habib, Aline" sort="Habib, Aline" uniqKey="Habib A" first="Aline" last="Habib">Aline Habib</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laor, Dana" sort="Laor, Dana" uniqKey="Laor D" first="Dana" last="Laor">Dana Laor</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yadav, Sudhanshu" sort="Yadav, Sudhanshu" uniqKey="Yadav S" first="Sudhanshu" last="Yadav">Sudhanshu Yadav</name>
<affiliation><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</nlm:affiliation>
<wicri:noCountry code="subField">Israel and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kupiec, Martin" sort="Kupiec, Martin" uniqKey="Kupiec M" first="Martin" last="Kupiec">Martin Kupiec</name>
<affiliation wicri:level="1"><nlm:affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv</wicri:regionArea>
<wicri:noRegion>Tel Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisman, Ronit" sort="Weisman, Ronit" uniqKey="Weisman R" first="Ronit" last="Weisman">Ronit Weisman</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and ronitwe@openu.ac.il.</nlm:affiliation>
<country wicri:rule="url">Israël</country>
<wicri:regionArea>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana</wicri:regionArea>
<wicri:noRegion>4353701 Ranana</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of biological chemistry</title>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromatin (genetics)</term>
<term>Chromatin (metabolism)</term>
<term>Gene Silencing (MeSH)</term>
<term>Heterochromatin (genetics)</term>
<term>Heterochromatin (metabolism)</term>
<term>Histones (genetics)</term>
<term>Histones (metabolism)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (metabolism)</term>
<term>Multiprotein Complexes (genetics)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Schizosaccharomyces (genetics)</term>
<term>Schizosaccharomyces (growth & development)</term>
<term>Schizosaccharomyces (metabolism)</term>
<term>Schizosaccharomyces pombe Proteins (genetics)</term>
<term>Schizosaccharomyces pombe Proteins (metabolism)</term>
<term>Telomere (genetics)</term>
<term>Telomere (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromatine (génétique)</term>
<term>Chromatine (métabolisme)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (génétique)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Complexes multiprotéiques (génétique)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Extinction de l'expression des gènes (MeSH)</term>
<term>Histone (génétique)</term>
<term>Histone (métabolisme)</term>
<term>Hétérochromatine (génétique)</term>
<term>Hétérochromatine (métabolisme)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines de Schizosaccharomyces pombe (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (métabolisme)</term>
<term>Schizosaccharomyces (croissance et développement)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Schizosaccharomyces (métabolisme)</term>
<term>Télomère (génétique)</term>
<term>Télomère (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chromatin</term>
<term>Heterochromatin</term>
<term>Histones</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Multiprotein Complexes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Schizosaccharomyces pombe Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chromatin</term>
<term>Heterochromatin</term>
<term>Histones</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Multiprotein Complexes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Schizosaccharomyces pombe Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Schizosaccharomyces</term>
<term>Telomere</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromatine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Complexes multiprotéiques</term>
<term>Histone</term>
<term>Hétérochromatine</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
<term>Télomère</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Schizosaccharomyces</term>
<term>Telomere</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chromatine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Complexes multiprotéiques</term>
<term>Histone</term>
<term>Hétérochromatine</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
<term>Télomère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Silencing</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Extinction de l'expression des gènes</term>
<term>Phosphorylation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The conserved serine/threonine protein kinase target of rapamycin (TOR) is a major regulator of eukaryotic cellular and organismal growth and a valuable target for drug therapy. TOR forms the core of two evolutionary conserved complexes, TOR complex 1 (TORC1) and TORC2. In the fission yeast <i>Schizosaccharomyces pombe</i>
, TORC2 responds to glucose levels and, by activating the protein kinase Gad8 (an orthologue of human AKT), is required for well-regulated cell cycle progression, starvation responses, and cell survival. Here, we report that TORC2-Gad8 is also required for gene silencing and the formation of heterochromatin at the <i>S. pombe</i>
 mating-type locus and at subtelomeric regions. Deletion of TORC2-Gad8 resulted in loss of the heterochromatic modification of histone 3 lysine 9 dimethylation (H3K9me2) and an increase in euchromatic modifications, including histone 3 lysine 4 trimethylation (H3K4me3) and histone 4 lysine 16 acetylation (H4K16Ac). Accumulation of RNA polymerase II (Pol II) at subtelomeric genes in TORC2-Gad8 mutant cells indicated a defect in silencing at the transcriptional level. Moreover, a concurrent decrease in histone 4 lysine 20 dimethylation (H4K20me2) suggested elevated histone turnover. Loss of gene silencing in cells lacking TORC2-Gad8 is partially suppressed by loss of the anti-silencer Epe1 and fully suppressed by loss of the Pol II-associated Paf1 complex, two chromatin regulators that have been implicated in heterochromatin stability and spreading. Taken together, our findings suggest that TORC2-Gad8 signaling contributes to epigenetic stability at subtelomeric regions and the mating-type locus in <i>S. pombe</i>
.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29632066</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>06</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>293</Volume>
<Issue>21</Issue>
<PubDate><Year>2018</Year>
<Month>05</Month>
<Day>25</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of biological chemistry</Title>
<ISOAbbreviation>J Biol Chem</ISOAbbreviation>
</Journal>
<ArticleTitle>TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.</ArticleTitle>
<Pagination><MedlinePgn>8138-8150</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.RA118.002270</ELocationID>
<Abstract><AbstractText>The conserved serine/threonine protein kinase target of rapamycin (TOR) is a major regulator of eukaryotic cellular and organismal growth and a valuable target for drug therapy. TOR forms the core of two evolutionary conserved complexes, TOR complex 1 (TORC1) and TORC2. In the fission yeast <i>Schizosaccharomyces pombe</i>
, TORC2 responds to glucose levels and, by activating the protein kinase Gad8 (an orthologue of human AKT), is required for well-regulated cell cycle progression, starvation responses, and cell survival. Here, we report that TORC2-Gad8 is also required for gene silencing and the formation of heterochromatin at the <i>S. pombe</i>
 mating-type locus and at subtelomeric regions. Deletion of TORC2-Gad8 resulted in loss of the heterochromatic modification of histone 3 lysine 9 dimethylation (H3K9me2) and an increase in euchromatic modifications, including histone 3 lysine 4 trimethylation (H3K4me3) and histone 4 lysine 16 acetylation (H4K16Ac). Accumulation of RNA polymerase II (Pol II) at subtelomeric genes in TORC2-Gad8 mutant cells indicated a defect in silencing at the transcriptional level. Moreover, a concurrent decrease in histone 4 lysine 20 dimethylation (H4K20me2) suggested elevated histone turnover. Loss of gene silencing in cells lacking TORC2-Gad8 is partially suppressed by loss of the anti-silencer Epe1 and fully suppressed by loss of the Pol II-associated Paf1 complex, two chromatin regulators that have been implicated in heterochromatin stability and spreading. Taken together, our findings suggest that TORC2-Gad8 signaling contributes to epigenetic stability at subtelomeric regions and the mating-type locus in <i>S. pombe</i>
.</AbstractText>
<CopyrightInformation>© 2018 Cohen et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cohen</LastName>
<ForeName>Adiel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Habib</LastName>
<ForeName>Aline</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laor</LastName>
<ForeName>Dana</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yadav</LastName>
<ForeName>Sudhanshu</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kupiec</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>the Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69977801, Tel Aviv, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weisman</LastName>
<ForeName>Ronit</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>From the Department of Natural and Life Sciences, Open University of Israel, University Road 1, 4353701 Ranana, Israel and ronitwe@openu.ac.il.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>04</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Biol Chem</MedlineTA>
<NlmUniqueID>2985121R</NlmUniqueID>
<ISSNLinking>0021-9258</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002843">Chromatin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006570">Heterochromatin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006657">Histones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029702">Schizosaccharomyces pombe Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C476401">Gad8 protein, S pombe</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076225">Mechanistic Target of Rapamycin Complex 2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D002843" MajorTopicYN="N">Chromatin</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020868" MajorTopicYN="Y">Gene Silencing</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006570" MajorTopicYN="N">Heterochromatin</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006657" MajorTopicYN="N">Histones</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076225" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 2</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012568" MajorTopicYN="N">Schizosaccharomyces</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029702" MajorTopicYN="N">Schizosaccharomyces pombe Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016615" MajorTopicYN="N">Telomere</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Akt PKB</Keyword>
<Keyword MajorTopicYN="Y">Epe1</Keyword>
<Keyword MajorTopicYN="Y">Paf1 complex</Keyword>
<Keyword MajorTopicYN="Y">Schizosaccharomyces pombe</Keyword>
<Keyword MajorTopicYN="Y">TORC2</Keyword>
<Keyword MajorTopicYN="Y">gene expression</Keyword>
<Keyword MajorTopicYN="Y">gene silencing</Keyword>
<Keyword MajorTopicYN="Y">heterochromatin</Keyword>
<Keyword MajorTopicYN="Y">mating-type locus</Keyword>
<Keyword MajorTopicYN="Y">subtelomeres</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>02</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>03</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>4</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>1</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>4</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29632066</ArticleId>
<ArticleId IdType="pii">RA118.002270</ArticleId>
<ArticleId IdType="doi">10.1074/jbc.RA118.002270</ArticleId>
<ArticleId IdType="pmc">PMC5971458</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>EMBO J. 2003 Jun 16;22(12):3073-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12805221</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2013 Mar;8(3):539-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23429716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 Mar;11(3):709-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12667453</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2009 Aug;29(16):4584-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19546237</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2013 Sep 1;27(17):1886-902</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24013502</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2015 Jun;25(6):872-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25778913</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2014 Aug 1;289(31):21727-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24928510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2017 Jan 23;27(2):175-188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28041796</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2017 Nov;18(11):643-658</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28804139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2006 Nov 1;119(Pt 21):4475-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17046992</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2006 Jun 9;22(5):681-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16762840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1998 Jul;14 (10 ):943-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9717240</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Epigenetics Chromatin. 2013 Sep 02;6(1):29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24044743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2010 Nov 23;20(22):1975-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21035342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2013 May;20(5):547-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23604080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Apr 6;292(5514):110-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11283354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2015 Jul 07;6(4):e00959</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26152587</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2002 Sep 13;297(5588):1833-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12193640</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2011 Mar;31(5):1088-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21189291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2011 Dec;189(4):1177-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22174183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2014 Oct 30;10(10):e1004740</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25356590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Jan 6;335(6064):96-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22144463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Cells. 2007 Dec;12(12):1357-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18076573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2007 Mar;175(3):1153-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17179073</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2005 Apr;6(4):315-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15809658</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2001 Mar 9;276(10):7027-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11096119</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Genet. 2001 May;39(3):166-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11409178</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2013 May 9;153(4):840-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23663782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2011 Sep 04;18(10):1132-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21892171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2007 Nov 14;26(22):4670-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17948055</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2005 Feb;169(2):539-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15466417</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2007 Nov;9(11):1263-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17952063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Biochem Mol Biol. 2008 Jul-Aug;43(4):277-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18756382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2002 Jan;4(1):89-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11780129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Perspect Biol. 2015 Jul 01;7(7):a018770</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26134317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2005 Aug;37(8):809-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15976807</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Soc Trans. 2009 Feb;37(Pt 1):273-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19143645</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Dec 21;294(5551):2539-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11598266</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Mar 7;278(10 ):8487-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12488447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2011 Jan 7;144(1):41-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21215368</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 2017 Oct;42(10 ):788-798</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28870425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2016 May 5;62(3):443-452</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27151441</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2014 Mar;15(3):155-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24556838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2017 Dec;18(12 ):2197-2218</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29079657</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2011 Jan 06;7(1):e1001268</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21253571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2016 Apr 22;291(17 ):9371-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26912660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21157483</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2003 Jan;23(2):629-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12509460</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2007 Apr;27(8):3154-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17261596</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2010 Mar 5;140(5):666-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20211136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2007 Apr;175(4):1549-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17449867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2015;14(6):848-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25590601</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2002 Sep;32(1):143-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12161753</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Spectr. 2016 Oct;4(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27763256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2016 Dec 1;30(23 ):2571-2580</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27941123</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2007 Jan;8(1):35-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17173056</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Cell Biol. 2011 Dec;23(6):744-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21963299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2009;10(3):R25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19261174</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2009 Jan 1;23(1):18-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19136623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2015 Dec;16(12):1673-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26518661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 Mar;11(3):721-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12667454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2017 Jul 27;547(7664):463-467</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28682306</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Open Biol. 2015 May;5(5):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25972440</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2017 Mar 9;168(6):960-976</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28283069</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2016 Mar 18;44(5):e45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26578583</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2003 Jun;23(12):4356-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12773576</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Jun 25;304(5679):1971-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15218150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2016 Nov 2;44(19):9180-9189</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27402158</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2000 Jun;155(2):551-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10835380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Apr 9;520(7546):248-252</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25807481</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2016 Aug;203(4):1733-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27343235</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2015 Nov 16;43(20):9766-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26275777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2016 Jul 1;129(13):2613-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27206859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2014;13(5):714-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24526113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2013 Nov 21;155(5):1061-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24210919</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2016 Mar 3;61(5):747-759</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26942678</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Jul 5;288(27):19649-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23703609</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2017 Oct 13;45(18):10333-10349</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28981863</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Israël</li>
</country>
</list>
<tree><noCountry><name sortKey="Cohen, Adiel" sort="Cohen, Adiel" uniqKey="Cohen A" first="Adiel" last="Cohen">Adiel Cohen</name>
<name sortKey="Yadav, Sudhanshu" sort="Yadav, Sudhanshu" uniqKey="Yadav S" first="Sudhanshu" last="Yadav">Sudhanshu Yadav</name>
</noCountry>
<country name="Israël"><noRegion><name sortKey="Habib, Aline" sort="Habib, Aline" uniqKey="Habib A" first="Aline" last="Habib">Aline Habib</name>
</noRegion>
<name sortKey="Kupiec, Martin" sort="Kupiec, Martin" uniqKey="Kupiec M" first="Martin" last="Kupiec">Martin Kupiec</name>
<name sortKey="Laor, Dana" sort="Laor, Dana" uniqKey="Laor D" first="Dana" last="Laor">Dana Laor</name>
<name sortKey="Weisman, Ronit" sort="Weisman, Ronit" uniqKey="Weisman R" first="Ronit" last="Weisman">Ronit Weisman</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000481 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000481 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29632066
   |texte=   TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29632066" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki